Product ID:LEUPROLIDE ACETATE
MSDS Date:10/01/1990
FSC:6505
NIIN:01-340-0851
Kit Part:Y
MSDS Number: BVXDY

Emergency Phone: 312-937-6100, CHEMTREC 800-424-9300

Info Phone: 800-622-2011

Cage: 60060

Telephone: 847-935-7177

Cage: 60060

LEUPROLIDE ACETATE

CAS: 74381-53-6

RTECS: OH6390000

LD50 LC50 Mixture:LD50 ORAL:NOT ACTIVE WHEN GIVEN ORALLY
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:INJECTION:IN CLINICAL USE, CONTINUOUS
ADMINISTRATION OF THERAPEUTIC DOSES ACTS AS POTENT, BUT REVERSIBLE
INHIBITOR OF GONADOTROPIN SECRETION BY THE PITUITARY, RESULTING IN
INHIBTION OF OVARIAN AND TES TICULAR STERIOD PRODUCTION.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:INJECTION: INCREASE IN LH, FSH, & MALE/ FEMALE
SEX HORMONES, REDUCTIONS IN HORMONES TO CASTRATE OR MENOPAUSAL
LEVEL, HOT FLASHES, SWEATS, IMPOTENCE, DECREASED LIBIDO/TESTICULAR
SIZE, HEADACHE, MOOD CH ANGES, AMENORRHEA, VAGINAL DRYNESS,
FERTILITY SUPPRESSION, DECREASED BONE DENSITY.
Medical Cond Aggravated by Exposure:DUE TO TEMPORARY INCREASE OF SEX
HORMONE LEVELS DURING FIRST FEW WEEKS OF TREATMENT, ISOLATED CASES
OF WORSENING IN SIGNS/SYMPTOMS OF HORMONALLY-DEPENDENT CONDITIONS
HAVE BEEN REPORTED.

First Aid:EYES/SKIN: FLUSH W/COPIOUS AMOUNTS OF WATER. INHALATION:
REMOVE TO FRESH AIR. INGESTION:SEEK MEDICAL HELP. THERE IS NO KNOWN
ANTIDOTE. PROVIDE SYMPTOMATIC OR SUPPORTIVE CARE, MONITORING
HORMONE/SEXUAL FUNCTION AS NECESSARY. OBTAIN MEDICAL ATTENTION IN
ALL CASES.

Extinguishing Media:USE APPROPRIATE MEDIA FOR UNDERLYING CAUSE OF FIRE.
Fire Fighting Procedures:WEAR PROTECTIVE CLOTHING & SELF-CONTAINED
BREATHING APPARATUS.

Spill Release Procedures:WEAR PROTECTIVE EQUIPMENT. SWEEP UP SPILLAGE.
AVOID DUST. PLACE IN APPROPRIATE CONTAINER FOR DISPOSAL. VENTILATE
& WASH SPILL AREA.

Handling and Storage Precautions:STORE ONLY IN CONTAINERS APPROVED FOR
STORAGE OF THIS MATERIAL. AVOID DUST.
Other Precautions:AVOID CONTACT W/SOLID OR ITS SOLUTIONS. WOMEN OF
CHILD BEARING POTENTIAL MUST BE EXCLUDED FROM WORKING DIRECTLY
W/PRODUCT WHICH IS NOT PACKAGED IN CLOSED CONTAINER.

Respiratory Protection:WEAR APPROVED RESPIRATOR W/HIGH EFFICIENCY
PARTICULATE FILTER OR SUPPLIED-AIR (IF HANDLING POWDER).
Ventilation:LOCAL VENTILATION TO CONTROL DUST AT ITS SOURCE
Protective Gloves:RUBBER, CHEMICALLY COMPATIBLE
Eye Protection:SAFETY GLASSES & GOGGLES
Other Protective Equipment:LONG SLEEVE CLOTHING
Work Hygienic Practices:AVOID MAKING OR INHALING DUST.
Supplemental Safety and Health
KEEP AWAY FROM CHILDREN. USE ONLY AS DIRECTED. PRODUCT IS A
PRESCRIPTION DRUG.

HCC:N1
Solubility in Water:COMPLETE
Appearance and Odor:WHITE, FLOCCULENT POWDER.

Stability Indicator/Materials to Avoid:YES
HYPOCHLORITE SOLUTIONS

Waste Disposal Methods:DISPOSE OF MATERIAL IN ACCORDANCE W/APPLICABLE
FEDERAL, STATE, & LOCAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.